Amine-Tunable Ruthenium Catalysts for Asymmetric Reduction of Ketones

作者：Rodriguez Sonia^*; Qu Bo; Fandrick Keith R; Buono Frederic; Haddad Nizar; Xu Yibo; Herbage Melissa A; Zeng Xingzhong; Ma Shengli; Grinberg Nelu; Lee Heewon; Han Zhengxu S; Yee Nathan K; Senanayake Chris H

来源：Advanced Synthesis & Catalysis, 2014, 356(2-3): 301-307.

DOI：10.1002/adsc.201300727

• asymmetric hydrogenation
• asymmetric transfer hydrogenation
• bisdihydrobenzooxaphosphole (BIBOP) ligands
• phosphorus ligands
• ruthenium

A series of efficient ruthenium catalysts has been developed for the asymmetric hydrogenation and transfer hydrogenation of ketones with high reactivities and selectivities. The new chiral bisdihydrobenzooxaphosphole (BIBOP)/diamine-ruthenium complexes catalyzed the enantioselective hydrogenation of substrates such as aryl and heteroaryl cyclic and alkyl ketones with substrate/catalyst (S/C) ratios of up to 100,000. The opposite sense of enantioselectivity can be obtained by proper selection of a diamine with a given chirality of the phosphine. The usefulness of the new system has been demonstrated in the asymmetric hydrogenation of a complex synthetic intermediate towards cholesteryl ester transfer protein (CETP) inhibitors at S/C 20,000 on large-scale operation.

• 出版日期2014-2-10