MicroRNA-505 inhibits proliferation and promotes apoptosis of colorectal cancer cells

作者：Wang, Yue; Zhu, Xinyi; Xuan, Chao^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(6): 10488-10496.

• miR-505
• CRC
• cytokine
• NF-kappa B
• proliferation
• apoptosis

MicroRNAs (miRs) have been demonstrated to play an important role in various cancers, but there has been no study on the role of miR-505 in colorectal cancer (CRC) and the mechanism of how miR-505 is regulated remains uncertain. In this study, we report that the expression of miR-505 can be strongly inhibited by some pro-tumor cytokines such as TNF-alpha, IL-1 beta, IL-17A and IL-6. In addition, NF-kappa B activation negatively regulates the expression levels of miR-505. The over-expression of miR505 can suppress proliferation and promote apoptosis of HCT116 and HT29 cells in vitro. In conclusion, our findings indicate that miR-505 might be a promising therapeutic target in patients with colorectal cancer.

• 出版日期2016
• 单位同济大学; 青岛大学