A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy

作者：Maity Santanu; Choudhary Priya; Manjunath Manu; Kulkarni Aditya; Murthy Niren^*

来源：Chemical Communications, 2015, 51(88): 15956-15959.

DOI：10.1039/c5cc05242d

In this report we present a polyketal, termed pADK, which has adamantane groups embedded in its backbone, and degrades into neutral excretable compounds. pADK was synthesized via click chemistry and had a MW of 49472 and a PDI of 1.74. We demonstrate here that pADK can increase the transfection efficiency of CD1800 (PEI of 1800 modified beta-cyclodextrin) 60 fold, yet cause no increase in toxicity.

• 出版日期2015