Alcohol consumption and risk of stroke and coronary heart disease among Japanese women: The Japan Public Health Center-based prospective study

作者：Ikehara Satoyo; Iso Hiroyasu^*; Yamagishi Kazumasa; Kokubo Yoshihiro; Saito Isao; Yatsuya Hiroshi; Inoue Manami; Tsugane Shoichiro

来源：Preventive Medicine, 2013, 57(5): 505-510.

DOI：10.1016/j.ypmed.2013.07.003

• Alcohol consumption
• Coronary heart disease
• Follow-up study
• Incidence
• Stroke

Objective. The study aims to examine the association between a wide range of alcohol consumption and risk of stroke and coronary heart disease. %26lt;br%26gt;Methods. The Japan Public Health Center-based prospective study was initiated in 1990 in Cohort land in 1993 in Cohort II, with follow-up until 2009. The sample consisted of 47,100 women aged 40-69 years. %26lt;br%26gt;Results. During an average of 16.7-years, the incidence of 1846 strokes and 292 coronary heart diseases was observed. Heavy drinking (%26gt;= 300 g ethanol/week) was associated with increased risk of total stroke. The multivariable hazard ratios for heavy versus occasional drinkers were 2.19 (95% confidence interval: 1.45-330) for total stroke, 2.25 (1.29-3.91) for hemorrhagic stroke, 224 (1.05-4.76) for intraparenchymal hemorrhage, 226 (1.01-5.09) for subarachnoid hemorrhage and 2.04 (1.09-3.82) for ischemic stroke. In the exposure-updated analysis, the positive association between heavy drinking and risks of total stroke, hemorrhagic stroke and intraparenchymal hemorrhage became more evident Light drinking (%26lt;150 g ethanol/week) was not associated with risk of ischemic stroke. There was also no association between alcohol consumption and risk of coronary heart disease. %26lt;br%26gt;Conclusion. Heavy drinking was associated with increased risk of hemorrhagic and ischemic strokes among Japanese women.

• 出版日期2013-11