An efficient synthesis of 2-chloropyrimidines via Pd-catalyzed regioselective dechlorination of 2,4-dichloropyrimidines in the presence of NaHCO(3)

作者：Zhang Yang Ming^*; Gu Min; Ma Hui; Tang Jie; Lu Wei; Nan Fa Jun

来源：Chinese Journal of Chemistry, 2008, 26(5): 962-964.

DOI：10.1002/cjoc.200890176

• 2,4-dichloropyrimidine
• palladium on carbon
• catalytic hydrogenation
• 2-chloropyrimidine

An efficient synthesis of 2-chloropyrimidines from readily accessible 2,4-dichloropyrimidines was achieved via Pd-catalyzed regioselective dechlorination in the presence NaHCO(3).

• 出版日期2008-5
• 单位中国科学院; 国家新药筛选中心; 华东师范大学; 中国科学院上海药物研究所; 河北医科大学