A Nonenzymatic Kinetic Resolution of (+/-)-trans-2-Arylcyclohexanols via Esterification Using Polymer-Supported DCC, DMAP, and 3 beta-Acetoxyetienic Acid

作者：Shamoto Kengo; Miyazaki Atsushi; Matsukura Mika; Kobayashi Yuki; Shioiri Takayuki; Matsugi Masato^*

来源：Synthetic Communications, 2013, 43(10): 1425-1431.

DOI：10.1080/00397911.2011.636498

• Esterification
• kinetic resolution
• nonenzymatic
• polymer-supported DCC

A nonenzymatic kinetic resolution of (+/-)-trans-2-arylcyclohexanols was carried out by esterification using polymer-supported N,N-dicyclohexylcarbodiimide (DCC), dimethylaminopyridine (DMAP), and 3-acetoxyetienic acid. The efficiency of the kinetic resolution was comparable to the enzymatic method when arylcyclohexanols bearing a condensed-aromatic ring were used. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communication (R) to view the free supplemental file.

• 出版日期2013-5-15