A Facile Synthesis of Bridged Polycyclic Naphthooxazocine Skeletons: Eight-Membered-Ring Constructions via Tandem Dinucleophilic Addition of Naphthalenols to Quinolinium Salts

作者:Moghaddam Firouz Matloubi*; Taheri Salman; Mirjafary Zohreh; Saeidian Hamdollah; Kiamehr Mostafa; Tafazzoli Mohsen
来源:Helvetica Chimica Acta, 2011, 94(1): 142-147.
DOI:10.1002/hlca.201000144

摘要

The efficient synthesis of bridged polycyclic naphthooxazocines 3 via addition of naphthalenols 1 as a bis-nucleophile to N-alkylquinolinium salts 2 is described (Scheme 1 and Table 2). This new approach provides a powerful entry into polycyclic structures containing bicyclic N,O-acetals related to bioactive compounds.

  • 出版日期2011-1