Microemulsion System for Topical Delivery of Thai Mango Seed Kernel Extract: Development, Physicochemical Characterisation and Ex Vivo Skin Permeation Studies

作者：Leanpolchareanchai Jira****; Padois Karine; Falson Francoise; Bavovada Rapepol; Pithayanukul Pimolpan^*

来源：Molecules, 2014, 19(11): 17107-17129.

DOI：10.3390/molecules191117107

• mango seed kernel extract
• microemulsion
• skin corrosion study
• skin irritation study
• skin permeation study
• stability
• topical delivery

A microemulsion system containing Thai mango seed kernel extract (MSKE, cultivar %26quot;Fahlun%26quot;) was developed and characterised for the purpose of topical skin delivery. The MSKE-loaded microemulsions were prepared by using the spontaneous emulsification method. Isopropyl myristate (IPM) was selected as the oil phase. A polyoxyethylene sorbitan monooleate and sorbitan monododecanoate (1:1, w/w) system was used as the surfactant phase; an aqueous mixture of different cosurfactants (absolute ethanol, 96.3% v/v ethanol, 1-propanol, 2-propanol or 1,2-propanediol) at a weight ratio of 1:1 was used as the aqueous phase. Among the cosurfactants studied, the 1-propanol aqueous mixture had the largest microemulsion region (48.93%) in the pseudo-ternary phase diagram. Microemulsions containing 1% MSKE demonstrated good physicochemical stability during a six-month study period at 25 +/- 2 degrees C/60% +/- 5% RH. The ex vivo skin permeation study demonstrated that the microemulsions exhibited a potent skin enhancement effect allowing MSKE to penetrate skin layers up to 60-fold higher compared with the control. Neither skin irritation nor skin corrosion was observed in ex vivo studies. The present study revealed that IPM-based microemulsion systems may be promising carriers to enhance skin penetration and delivering MSKE for topical treatment.

• 出版日期2014-11