Asymmetric Synthesis of Sulfinamides Using (-)-Quinine as Chiral Auxiliary

作者：Zhang Yongda^*; Chitale Sampada; Goyal Navneet; Li Guisheng; Han Zhengxu S; Shen Sherry; Ma Shengli; Grinberg Nelu; Lee Heewon; Lu Bruce Z; Senanayake Chris H

来源：Journal of Organic Chemistry, 2012, 77(1): 690-695.

DOI：10.1021/jo201825b

A process has been designed and demonstrated for the asymmetric synthesis of sulfinamides using quinine as auxiliary. A variety of chiral sulfinamides including N-alkyl sulfinamides with diverse structure were prepared in good yields and excellent enantioselectivity starting from easily available and inexpensive reagents. The auxiliary quinine could be recovered and recycled.

• 出版日期2012-1-6