Visible light promoted copper-catalyzed Markovnikov hydration of alkynes at room temperature

作者：Niu, Teng-Fei^*; Jiang, Ding-Yun; Li, Si-Yuan; Shu, Xing-Ge; Li, Huan; Zhang, Ai -Ling; Xu, Jia-Yu; Ni, Bang-Qing^*

来源：Tetrahedron Letters, 2017, 58(12): 1156-1159.

DOI：10.1016/j.tetlet.2017.02.004

• Visible-light promoted reaction
• Copper salt
• Alkynes
• Hydration
• Methyl ketones

A new and efficient method for the hydration of alkynes to the corresponding ketones was successfully developed. The hydration process proceeds smoothly at room temperature with 1% mol of CuCI as catalyst under visible light irradiation. This protocol is applicable to various alkynes, including aromatic alkynes, polycyclic aromatic and heterocyclic aromatic excellent regioselectivity in good to excellent yields.

• 出版日期2017-3-22
• 单位江南大学