The human cytomegalovirus TRL11/IRL11-encoded Fc gamma R binds differentially to allelic variants of immunoglobulin G1

作者：Namboodiri Aryan M; Pandey Janardan P^*

来源：Archives of Virology, 2011, 156(5): 907-910.

DOI：10.1007/s00705-011-0937-8

Human cytomegalovirus (HCMV) has evolved several immune-evasion strategies. One strategy involves encoding Fcgamma receptor (Fc gamma R)-like proteins that thwart the Fc gamma-mediated effector functions. Our aim was to determine whether GM allotypes-immunoglobulin gamma chain determinants expressed primarily on the Fc segment-modulate this viral strategy through differential binding to the viral Fc gamma R. Results of our ELISA binding studies show that the mean absorbance values for binding to the HCMV TRL11/IRL11-encoded Fc gamma R were higher for IgG1 expressing the GM 3 allotype than for those expressing the allelic GM 1,2,17 determinants (p = 0.0005), a finding with potential implications for genetic etiology of HCMV-associated diseases.

• 出版日期2011-5