Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders

作者：Kleinhans Natalia M^*; Richards Todd; Weaver Kurt; Johnson L Clark; Greenson Jessica; Dawson Geraldine; Aylward Elizabeth

来源：Neuropsychologia, 2010, 48(12): 3665-3670.

DOI：10.1016/j.neuropsychologia.2010.07.022

• Autism
• Asperger s disorder
• Amygdala
• Anxiety
• Emotional face processing
• Fusiform face area

Difficulty interpreting facial expressions has been reported in autism spectrum disorders (ASD) and is thought to be associated with amygdala abnormalities To further explore the neural basis of abnormal emotional face processing in ASD we conducted an fMRI study of emotional face matching in high-functioning adults with ASD and age IQ, and gender matched controls In addition we investigated whether there was a relationship between self-reported social anxiety and fMRI activation During fMRI scanning study participants were Instructed to match facial expressions depicting fear or anger The control condition was a comparable shape-matching task The control group evidenced significantly increased left prefrontal activation and decreased activation in the occipital lobes compared to the ASD group during emotional face matching Further within the ASD group greater social anxiety was associated with Increased activation in right amygdala and left middle temporal gyrus and decre

• 出版日期2010-10