Dectin-1 plays a redundant role in the immunomodulatory activities of beta-glucan-rich ligands in vivo

作者：Marakalala Mohlopheni J; Williams David L; Hoving Jennifer C; Engstad Rolf; Netea Mihai G; Brown Gordon D^*

来源：Microbes and Infection, 2013, 15(6-7): 511-515.

DOI：10.1016/j.micinf.2013.03.002

• Innate immunity
• Immunomodulation
• Dectin-1
• Beta-glucan
• MODS
• Staphylococcus aureus

beta-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified beta-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these beta-glucan rich compounds had marked effects in vivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models.

• 出版日期2013-6
• 单位河北医科大学