Ureaphosphanes as Hybrid, Anionic or Supramolecular Bidentate Ligands for Asymmetric Hydrogenation Reactions

作者：Meeuwissen Jurjen; Detz Remko; Sandee Albertus J; de Bruin Bas; Siegler Maxime A; Spek Anthony L; Reek Joost N H^*

来源：European Journal of Inorganic Chemistry, 2010, (19): 2992-2997.

DOI：10.1002/ejic.201000213

• Asymmetric hydrogenation
• Rhodium
• Phosphorus ligands
• Coordination chemistry
• Hydrogen bonds

We report the coordination behavior of ureaphosphane ligand 1[2-(diphenylphosphanyl)ethyl]-3-phenylurea (L1) towards different rhodium precursor complexes. Depending on the nature of the anion and the ligand/metal ratio, L1 acts either as a hybrid P, O-coordinating chelate, as an anionic P,N-coordinating chelate or as a supramolecular (hydrogen-bonded) bidentate ligand. The different types of complexes were investigated in the asymmetric hydrogenation of three olefinic substrates using ureaphosphanes L2 and L3, which are chiral analogues of L1. For methyl 2-acetamidoacrylate (Si) and dimethyl itaconate (S2) the neutral complex [Rh(L2-kappa(2)P,N)(cod)], containing an anionic RN-coordinating ureaphosphane ligand, provided the best enantioselectivity (69.2 and 24.3 %, respectively). For N-(3,4-dihydro-2-naphth-alenyl)acetamide (S3) the best enantioselectivity was obtained with the cationic complex [Rh(L3-kappa(2)P,O)(nbd)]BF(4), containing a hybrid PO-coordinating ureaphosphane ligand (86.1 %).

• 出版日期2010-7