科研之友
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摘要
IN THIS PAPER we consider the coupling between chemical and mechanical effects accompanying the diffusion of calcium, either in biological tissues or in a single long cell. The tissue is treated either as a 3-D, or as a quasi-2-D thin layer, of viscoelastic medium, whereas the cell is represented as a thin long cylinder. In particular, the influence of viscosity on the properties of calcium travelling waves is studied. In principle, we explore here-the simplest model of calcium diffusion which is based on an effective diffusion coefficient, thus neglecting the details of the role played by buffers. The mechano-chemical coupling in the model is realized by the presence of a traction tensor, in addition to the viscoelastic stress tensor in the mechanical equations, and the strain tensor in the source term of the calcium diffusion equation, as proposed in [1-4]. Our aim is to provide a simple and effective theory, which can be useful in studying various effects influencing propagation of calcium waves. Since in the absence of viscosity the whole mechano-chemical system for calcium and buffers is easily reduced to the "chemical one", i.e. it consists only of reaction diffusion equations, therefore we decided to perform expansion with respect to the viscosity. Treating, thus, viscous forces as a perturbation, we reduce the problem in each case to a single reaction diffusion equation for the calcium concentration. In this way we avoid the question of the existence of travelling wave solutions as for the so obtained models, their existence follows simply from already known theorems [5-9].
- 出版日期2010
