An E/Z conformational behaviour study on the trypanocidal action of lipophilic Spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids

作者：Tsatsaroni Alexandra; Zoidis Grigoris; Zoumpoulakis Panagiotis; Tsotinis Andrew; Taylor Martin C; Kelly John M; Fytas George^*

来源：Tetrahedron Letters, 2013, 54(25): 3238-3240.

DOI：10.1016/j.tetlet.2013.03.128

• Lipophilic hydroxamic acid derivatives
• E/Z conformational behaviour
• Trypanocidal action
• NMR
• Molecular modelling studies

An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids 5 and 6, and their primary (nonmethylated) congeners la and 2, based on their E/Z conformational behaviour in DMSO, is presented.

• 出版日期2013-6-19