Acute Tubulointerstitial Nephritis Associated with Infliximab in a Patient with Crohn's Disease

作者：Ota Mineto; Iwai Hideyuki; Imai Kaori; Kamiya Mari; Yoshihashi Nakazato Yoko; Miyasaka Nobuyuki; Kohsaka Hitoshi^*

来源：Internal Medicine, 2016, 55(10): 1367-1370.

DOI：10.2169/internalmedicine.55.5834

• acute tubulointerstitial nephritis
• Crohn's disease
• infliximab

We report the findings of a 46-year-old man, who presented with fever and renal dysfunction while undergoing treatment for Crohn's disease with infliximab (IFX). Remittent fever and renal dysfunction with urinary casts developed and lasted for 3 weeks without deterioration of Crohn's disease. Renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After the discontinuation of IFX, his fever and renal abnormalities resolved. We herein report the first known case of ATIN associated with IFX.

• 出版日期2016