Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase

作者：Ehteshami Maryam; Zhou Longhu; Amiralaei Sheida; Shelton Jadd R; Cho Jong Hyun; Zhang Hongwang; Li Hao; Lu Xiao; Ozturk Tugba; Stanton Richard; Amblard Franck; McBrayer Tamara R; Coats Steven J; Schinazi Raymond F^*

来源：Antimicrobial Agents and Chemotherapy, 2017, 61(8): e00492-17.

DOI：10.1128/AAC.00492-17

• antiviral agents
• hepatitis C virus
• toxicity

Nucleoside analog inhibitors (NAIs) are an important class of antiviral agents. Although highly effective, some NAIs with activity against hepatitis C virus (HCV) can cause toxicity, presumably due to off-target inhibition of host mitochondrial RNA polymerase (POLRMT). The in vitro nucleotide substrate specificity of POLRMT was studied in order to explore structure-activity relationships that can facilitate the identification of nontoxic NAIs. These findings have important implications for the development of all anti-RNA virus NAIs.

• 出版日期2017-8