Molecular subtyping of diffuse large B-cell lymphoma: update on biology, diagnosis and emerging platforms for practising pathologists

作者：Gifford Grace K^*; Gill Anthony J; Stevenson William S

来源：Pathology, 2016, 48(1): 5-16.

DOI：10.1016/j.pathol.2015.11.017

• Diffuse large B-cell lymphoma
• subclassification
• cell-of-origin assignment
• molecular profiling and subtyping
• molecular biology
• novel diagnostic testing

Molecular classification of diffuse large B-cell lymphoma (DLBCL) is critical. Numerous methodologies have demonstrated that DLBCL is biologically heterogeneous despite morphological similarities. This underlies the disparate outcomes of treatment response or failure in this common non-Hodgkin lymphoma. This review will summarise historical approaches to lymphoma classifications, current diagnosis of DLBCL, molecular techniques that have primarily been used in the research setting to distinguish and subclassify DLBCL, evaluate contemporary diagnostic methodologies that seek to translate lymphoma biology into clinical practice, and introduce novel diagnostic platforms that may overcome current issues. The review concludes with an overview of key molecular lesions currently identified in DLBCL, all of which are potential targets for drug treatments that may improve survival and cure.

• 出版日期2016-1
• 单位河北医科大学