An ionic liquid-modified nano-vehicle to construct nano-models of catalase to target mitochondria

作者：Yang, Xia; Chen, Qiu-Yun^*; Kong, Meng-Yun; Qu, Ling-Ling; Geng, Zhi-Rong; Wang, Zhi-Lin

来源：Journal of Materials Chemistry, 2012, 22(38): 20299-20304.

DOI：10.1039/c2jm34354a

• CANCER
• NANOPARTICLES
• PROGRESSION
• VESICLES
• HYPOXIA

A new functional ionic liquid (IL) (IL = 4-acetyl-N-propenylpyridinium hexafluorophosphate) and methoxy poly(ethylene glycol) (PEG)-modified central hollow nano-vehicle (SiO2@IL-PEG) was synthesized and assembled with Mn(II) complexes, leading to two new kinds of nano-mimics of catalase. In vitro assay results show that the synthesized nano-mimics of catalase can decrease the oxygen consumption and mitochondria potential, which leads to effective inhibition of the proliferation of HepG-2 cells. Taken together, this study demonstrates that the ionic liquid and PEG-modified nano-vehicle is a good carrier of nano-models of catalase to target mitochondria, which would give a new path to develop mediators of cancer progression and the metabolite of oxygen.

• 出版日期2012
• 单位江苏大学; 南京大学; 现代配位化学国家重点实验室