Antibacterial and cytotoxicity effects of biogenic palladium nanoparticles synthesized using fruit extract of Couroupita guianensis Aubl

作者：Gnanasekar Sathishkumar; Murugaraj Jeyaraj; Dhivyabharathi Balakrishnan; Krishnamoorthy Varunkumar; Jha Pradeep K; Seetharaman Prabukumar; Vilwanathan Ravikumar; Sivaperumal Sivaramakrishnan^*

来源：Journal of Applied Biomedicine, 2018, 16(1): 59-65.

DOI：10.1016/j.jab.2017.10.001

• Palladium nanoparticles
• X-ray diffraction
• Polyols
• Bactericidal
• Lung cancer

Herein, we report a facile route to synthesize palladium nanoparticles (CGPdNPs) using the aqueous fruitextract of C. guianensis Aubl. as a potent biological reducing agent. Reduction of PdCl2 solution into their nano scale was confirmed with the formation of a black precipitate which gives a reduced absorbance in UV-vis spectroscopy. Fourier transform infrared spectroscopy (FTIR) reveals the active role of phenolic constituents from C. guianensis in reduction and surface functionalization of nanoparticles (NPs). Dynamic light scattering (DLS) and zeta potential analysis confirms the generation of polydispersed highly stable NPs with large negative zeta value (-17.7 mV). Interestingly, X-ray Diffraction (XRD) pattern shows that the synthesized CGPdNPs were face centered cubic crystalline in nature. The HRTEM micrographs of CGPdNPs displays well-dispersed, spherical NPs in the size ranges between 5 and 15 nm with an average of 6 nm. It was also noticed that the synthesized CGPdNPs possess an effective antimicrobial activity against different bacterial pathogens. On the other hand, in vitro cell viability (MTT) assays reveals that the synthesized CGPdNPs exhibited an extraordinary anticancer properties. Eventually, hemocompatibility assay depicts the safe nature of synthesized NPs for biomedical application.

• 出版日期2018-2