Detection of highly prevalent hepatitis B virus co-infection with HIV in Indonesia

作者：Utsumi Takako^*; Yano Yoshihiko; Lusida Maria I; Nasronudin; Amin Mochamad; Juniastuti; Soetjipto; Hotta Hak; Hayashi Yoshitake

来源：Hepatology Research, 2013, 43(10): 1032-1039.

DOI：10.1111/hepr.12053

• co-infection
• hepatitis B virus
• HIV
• Indonesia

AimThe prevalence of hepatitis B virus (HBV) co-infection with HIV is increasing worldwide because of shared transmission routes. This study aimed to assess the prevalence of HBV and HIV co-infection in Indonesia, and its molecular and clinical characteristics. %26lt;br%26gt;MethodsA total of 118 serum samples from HIV-infected patients (age 33.38.9 years, 99 male, 19 female) collected in 2009 were serologically examined. HBV DNA was assessed by polymerase chain reaction (PCR) analysis targeting the S region. %26lt;br%26gt;ResultsOverall, 15.3% (18/118) of the patients were hepatitis B surface antigen (HBsAg) positive, whereas 27.1% (32/118) were HBsAg negative but HBV DNA positive, and were considered to have occult HBV infection. HBsAg antibodies and/or HBV core antibodies were detected in 45.6% (31/68) of HBV DNA negative patients. %26lt;br%26gt;ConclusionHBV co-infection, including occult HBV infection, was common in Indonesian HIV patients. Hepatic damage by the interaction of host immunity and HBV is still a remaining issue in these immunosuppressive patients, and further study will be needed.

• 出版日期2013-10