A Domino Desulfitative Coupling/Acylation/Hydration Process Cocatalyzed by Copper(I) and Palladium(II): Synthesis of Highly Substituted and Functionalized Pyrimidines

作者：Quan Zheng Jun^*; Hu Wang Hua; Jia Xiao Dong; Zhang Zhang; Da Yu Xia; Wang Xi Cun

来源：Advanced Synthesis & Catalysis, 2012, 354(16): 2939-2948.

DOI：10.1002/adsc.201200402

• C-C bond formation
• C-N bond formation
• copper(I) carboxylates
• cross-coupling
• 3,4-di-hydropyrimindine-2-thiones
• palladium

A domino desulfitative coupling/acylation/hydration process to synthesize C-2-(2-oxo-2-phenylethylidene)- and N-3-carbonyl-substituted pyrimidines by unprecedented C-C and C-N cross-coupling reactions is described. This methodology couples 3,4-dihydropyrimidine-2-thiones and alkynes under modified LiebeskindSrogl conditions using palladium acetate and copper(I) carboxylate. Remarkably the copper(I) carboxylates simultaneously act as desulfitative and acylation reagents in the reaction.

• 出版日期2012-11
• 单位西北师范大学