A convenient, rapid microwave assisted synthesis of some novel 3-[(4-chloro-3-methylphenoxy)methyl]-6-aryl-5,6-dihydro-[1,2,4]triazolo[ 3,4-b][1,3,4]thiadiazoles using acidic alumina

作者：Raval Jignesh P^*; Patel Hemul V; Patel Pradip S; Desai Kishor R

来源：Journal of Saudi Chemical Society, 2010, 14(4): 417-421.

DOI：10.1016/j.jscs.2010.05.005

• Microwave
• Triazolo[3,4-b][1,3,4]thiadiazole
• Acidic alumina

A facile synthesis of 3-[(4-chloro-3-methylphenoxy)methyl]-6-aryl-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 3a-n has been achieved by microwave promoted condensation of 3-mercapto-4-amino-5-[(4-chloro-3-methylphenoxy)methyl]-4H-1,2,4-triazole 1 with various aromatic aldehydes 2a-n in presence of catalytic amount of p-TsOH (para-toluenesulphonic acid). The structures of 3a-n are supported by IR and (1)H and (13)C, NMR spectral data.

• 出版日期2010-10