Asthma and risk of coronary heart disease A meta-analysis of cohort studies

作者：Liu, Huai^*; Fu, Ying; Wang, Kunpeng

来源：Annals of Allergy Asthma & Immunology, 2017, 118(6): 689-695.

DOI：10.1016/j.anai.2017.03.012

• ADULT-ONSET ASTHMA
• CARDIOVASCULAR-DISEASE
• MYOCARDIAL-INFARCTION
• LUNG-FUNCTION
• SYSTEMATIC ANALYSIS
• BRONCHIAL-ASTHMA
• LIFE EXPECTANCY
• GLOBAL BURDEN
• ASSOCIATION
• ATHEROSCLEROSIS

Background: Few studies have investigated the incidence of coronary heart disease (CHD) in patients with asthma, and their results remain inconclusive.
Objective: To conduct a meta-analysis to determine whether asthma increases the risk of CHD.
Methods: A systematic literature search of the PubMed and Embase databases from inception to August 2016, complemented with references screening of relevant articles and reviews, was performed to identify eligible studies. Only longitudinal cohort studies were included in our meta-analysis.
Results: The retrieval process yielded 7 studies (12 asthma cohorts) with 495,024 patients. Data pooling across the cohorts revealed that asthma was associated with an increased risk of CHD (hazard ratio [HR], 1.42; 95% confidence interval [CI], 1.30e1.57; P <.001), without significant heterogeneity across the studies (I-2 = 26%, P = .19). This epidemiologic association was more pronounced in female than in male patients (female: HR, 1.50; 95% CI, 1.41e1.59; male: HR, 1.31; 95% CI, 1.16e1.47; P for interaction = .046). In addition, subgroup and sensitivity analyses supported the positive correlation between asthma and incident CHD.
Conclusion: Asthma is related to an increased incidence of CHD, particularly in women. Clinicians should be aware of this association when faced with a patient with asthma. Further investigations are required to examine how this excess risk should be managed in routine practice.

• 出版日期2017-6
• 单位荆楚理工学院; 湖北医药学院