科研之友
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摘要
Freezing of gait is an episodic gait disorder, characterized by the inability to generate effective forward stepping movements. The pathophysiology underlying freezing of gait remains insufficiently understood, and this hampers the development of better treatment strategies. Preliminary evidence suggests that impaired force control during walking may contribute to freezing episodes, with difficulty to unload the swing leg and initiate the swing phase. Here, we used external loading to manipulate force control and to investigate its influence on freezing of gait. Twelve Parkinson's disease patients with freezing of gait performed three contrasting tasks: (1) loaded gait while wearing a belt fortified with lead weights; (2) weight-supported gait using a parachute harness connected to a rigid metal cable running above the gait trajectory; and (3) normal gait. Gait tasks were used to provoke freezing episodes, including rapid 360A degrees turns. Freezing episodes were quantified using blinded, videotaped clinical assessment. Furthermore, ground reaction forces and body kinematics were recorded. Loading significantly increased the mean number of freezing episodes per trial compared to the normal gait condition (P < 0.05), but the effect of weight support was not consistent. Loading particularly increased the number of freezing episodes during rapid short steps. Step length was significantly smaller during loaded gait compared to normal gait (P < 0.05), but changes in anticipatory postural adjustments were not different. Our results may point to impaired force control playing a key role in freezing of gait. Future studies should further investigate the mechanism, i.e., the contribution of deficient load feedback, and evaluate which forms of weight support might offer treatment opportunities.
- 出版日期2014-5
