Microwave-Promoted Michael Addition of Azaheterocycles to alpha,beta-Unsaturated Esters and Acid under Solvent-Free Conditions

作者：Dubois Lilian; Acher Francine C; McCort Tranchepain Isabelle^*

来源：Synlett, 2012, (5): 791-795.

DOI：10.1055/s-0031-1290164

• microwave irradiation
• Michael addition
• azaheterocycles
• phase-transfer catalysis
• green chemistry

Regioselective Michael addition of N-9 adenine to ethyl acrylate under microwave activation in solid-liquid solvent-free phase-transfer catalysis using TBAB as catalyst and DABCO as base was extended to tert-butyl acrylate and acrylic acid. Under these conditions and in the presence of a catalytic amount of KOH, first Michael addition of indole and indolylmaleimide to acrylates is also reported.

• 出版日期2012-3