Desymmetrization of Hepta-1,6-dien-4-ol by a Highly Stereoselective Tandem Prins-Ritter Cyclization: Access to New THP Acetamides

作者：Glachet Thomas; Fache Fabienne; Pelotier Beatrice; Piva Olivier

来源：Synthesis, 2017, 49(23): 5197-5202.

DOI：10.1055/s-0036-1588521

<jats:p>Prins–Ritter cyclization performed from hepta-1,6-dien-4-ol and various aldehydes, promoted by bismuth(II) triflate, afforded N-(tetrahydropyranyl)acetamides in moderate to high yields. Subsequent Wacker-type oxidation using Dess–Martin periodinane (DMP) delivered the corresponding ketones.</jats:p>

• 出版日期2017-12