A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid

作者：Kaur Rajbir; Khan Sheema; Chib Renu; Kaur Tandeep; Sharma Parduman Raj; Singh Jaswant; Shah Bhahwal Ali^*; Taneja Subhash Chandra

来源：European Journal of Medicinal Chemistry, 2011, 46(4): 1356-1366.

DOI：10.1016/j.ejmech.2011.01.061

• Triterpenoids
• Boswellic acids
• Anti-cancer
• Cytotoxicity
• Apoptosis

Semi-synthetic analogues of beta-boswellic acid (BA) and 11-keto-beta-boswellic acid (MBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical carcinoma (HeLa) cells. 2-Cyano analogues of both the triterpenes were observed to have significant cytotoxicity against both the cells, displaying cytotoxicity in HL-60 cells at low concentrations. Further investigations suggested the proapoptotic potential associated with the two molecules to induce cytotoxicity in HL-60 cells, where one of them showed early proapoptotic effect as evidenced by several biological end-points of the apoptosis such as annexinV binding, DNA fragmentation and increase in sub-G0 DNA fraction and apoptotic bodies formation (Hoechst 33258 staining and SEM studies).

• 出版日期2011-4