Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population

作者：Tanabe Tsuyoshi^*; Yamaguchi Natsu; Matsuda Koichi; Yamazaki Keiko; Takahashi Satoshi; Tojo Arinobu; Onizuka Makoto; Eishi Yoshinobu; Akiyama Hideki; Ishikawa Jun; Mori Takehiko; Hara Masamichi; Koike Kazutoshi; Kawa Keisei; Kawase Takakazu; Morishima Yasuo; Amano Hiroki; Kobayashi Miura Mikiko; Kakamu Takeyasu; Nakamura Yusuke; Asano Shigetaka; Fujita Yasuyuki

来源：International Journal of Hematology, 2011, 93(6): 771-778.

DOI：10.1007/s12185-011-0860-5

• NLR
• Crohn's disease
• Innate immunity
• GVHD
• Leukemia
• NOD2

Members of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family participate in the innate immune system, exerting widespread effects on cytokine secretion, autophagy, and apoptosis. Recent studies in Caucasians revealed the association between mutants of NOD2, a member of the NLR family, and severity of acute graft-versus-host disease (GVHD). NOD2 polymorphism screening has been recommended for donor selection and risk assessment at bone marrow transplantation. To investigate whether NOD2 plays a role in the pathogenesis of GVHD in a Japanese population, we examined DNA from 142 bone marrow transplant patient/donor pairs to detect genetic variation in the NOD2 gene. No genetic variants of NOD2 were associated with the severity of acute GVHD in our patients. However, a weak association between a single nucleotide polymorphism in the NOD2 gene (R471C) and acute myeloid leukemia in the bone marrow patients (p = 0.029, odds ratio 4.08, 95% CI 1.22-13.67) was detected. This polymorphism was not prevalent in 479 Crohn's disease (CD) patients in Japan. These results suggest that, in the Japanese population, unlike the Caucasian, NOD2 is not a major contributor to susceptibility to severe acute GVHD.

• 出版日期2011-6
• 单位河北医科大学