Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease

作者：Oono Takashi; Yamasaki Takahiro^*; Zaitsu Junichi; Saeki Issei; Iwamoto Takuya; Harima Yumiko; Marumoto Yoshio; Hidaka Isao; Urata Yohei; Ishikawa Tsuyoshi; Takami Taro; Segawa Makoto; Uchida Koichi; Terai Shuji; Kunitugu Ichiro; Tanabe Tsuyoshi; Sakaida Isao

来源：Hepatology Research, 2014, 44(10): E54-E62.

DOI：10.1111/hepr.12213

• chronic hepatitis
• hepatic fibrosis
• hepatitis C virus
• insulin resistance
• liver cirrhosis
• tyrosine

Aim: Insulin resistance (IR) increases during the early stages of hepatitis C virus (HCV)-related chronic liver disease and is a sign of poor prognosis as well as a risk factor for hepatic fibrosis and hepatocellular carcinoma. We aimed to determine the factors affecting IR in HCV-related chronic liver disease. %26lt;br%26gt;Methods: We retrospectively examined 71 patients with HCV-related chronic liver disease and analyzed various parameters, including amino acids, as possible predictors of IR. IR was assessed using the Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR). Amino acids were assayed by examining branched-chain amino acids (BCAA), tyrosine level, and the ratio of BCAA to tyrosine level (BTR). %26lt;br%26gt;Results: HOMA-IR was significantly correlated with body mass index, platelet count, prothrombin time, hemoglobin, total bilirubin, total protein, albumin, total cholesterol, fasting glucose, BTR (r = -0.46, P = 0.0001) and tyrosine (r = 0.55, P %26lt; 0.0001). However, BCAA were not significantly correlated with HOMA-IR (r = -0.21, P = 0.082). In multivariate analysis, only two factors were identified as independent parameters contributing to a HOMA-IR of 2.5 or more: total cholesterol (odds ratio [OR], 6.511; 95% confidence interval [95% CI], 1.554-27.284; P = 0.010) and tyrosine (OR, 4.839; 95% CI, 1.087-21.549; P = 0.039). %26lt;br%26gt;Conclusion: Serum tyrosine levels may be associated with IR in patients with HCV-related chronic liver disease.

• 出版日期2014-10