Assessment of risk for pulmonary tuberculosis after non-reactive tuberculin skin testing among patients with HIV infection in a resource-limited setting

作者：Khawcharoen**** T; Apisarnthanarak A^*; Mundy L M

来源：International Journal of STD & AIDS, 2008, 19(12): 843-847.

DOI：10.1258/ijsa.2008.008123

• risk factors
• tuberculin skin test
• human immunodeficiency virus
• tuberculosis
• resource-limited setting

A cross-sectional study of 350 patients with HIV-1 infection was conducted to identify risks for pulmonary Mycobacterium tuberculosis (TB) after non-reactive two-step tuberculin skin tests (TST). Among 219 patients (62.6%) with non-reactive TST, independent risks for active pulmonary TB were prior known TB exposure (adjusted odds ratio [aOR] = 16.00, 95% confidence interval [CI] = 2.00-26.36, P = 0.008), CD4 <100 cells/mu L (aOR = 2.50, 95% CI = 1.30-6.50, P = 0.04) and less than secondary-school education (aOR = 2.60, 95% CI = 1.50-6.90, P = 0.02). Our findings suggest that further diagnostic work-up for pulmonary TB is warranted among patients with HIV infection, non-reactive TSTs and either prior known TB exposure, CD4 counts < 100 cells/mu L or limited formal education.

• 出版日期2008-12