Analysis of the clinical value of F-18-FDG PET/CT in hepatic alveolar echinococcosis before and after autologous liver transplantation

作者：Qin, Yongde; Li, Xiaohong; Zhang, Qizhou; Xie, Bin; Ji, Xuewen; Li, Yubin; Yiblayan, Amina; Wen, Hao^*

来源：Experimental and Therapeutic Medicine, 2016, 11(1): 43-48.

DOI：10.3892/etm.2015.2857

• liver alveolar echinococcosis
• autologous liver transplantation
• positron emission tomography
• deoxyglucose

The aim of this study was to evaluate the clinical value of F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) in advanced liver alveolar echinococcosis (LAE) prior to and following autologous liver transplantation (ALT). The biodistribution of lesions in 8 patients was recorded using F-18-FDG PET/CT prior to and following surgery. The maximum standardized uptake value (SUVmax) of the lesions was also measured and compared with the pathological results. The overall hepatic peri-lesion SUVmax of the patients was 3.57 +/- 1.21, and the delayed SUVmax was 4.19 +/- 1.70. The diagnostic sensitivity of 18F-FDG PET/CT in LAE was 91.67%, with a specificity of 60.00% and accuracy of 82.35%. The positive predictive value was 84.62%, and the negative predictive value was 75.00%. SUVmax values of the surviving liver were 1.23 +/- 0.78 after 1 month, 1.15 +/- 0.67 after 3 months and 0.85 +/- 0.35 after 6 months. Compared with normal liver values (0.95 +/- 0.19), the 1-month SUVmax was significantly different. The SUVmax in 3 patients with high-lividity lesions was 2.05 +/- 0.72, and the delayed SUVmax was 3.15 +/- 0.83; 3 months after transplantation, the SUVmax was 1.85 +/- 0.62, and the delayed SUVmax was 2.95 +/- 0.79, revealing no significant difference. In conclusion, F-18-FDG PET/CT is effective for determining the biological boundary of LAE and shows important clinical value in determining the metabolic activities of the surviving liver following ALT.

• 出版日期2016-1
• 单位新疆医科大学