Afatinib: a second-generation EGF receptor and ErbB tyrosine kinase inhibitor for thetreatment of advanced non-small-cell lung cancer

作者：Marquez Medina Diego; Popat Sanjay

来源：Future Oncology, 2015, 11(18): 2525-2540.

DOI：10.2217/fon.15.183

• EGF receptor
• ErbB2
• ErbB4
• adenocarcinoma
• afatinib
• irreversible
• non-small-cell lung cancer
• second generation
• squamous
• tyrosine kinase inhibitor

First-generation reversible EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs) changed our understanding of advanced non-small-cell lung cancer biology and behavior. The presence of sensitizing EGFR mutations in advanced non-small-cell lung cancer defines a subset of patients with a better progno...

• 出版日期2015