Downregulated expression of hsa_circ_0074362 in gastric cancer and its potential diagnostic values

作者：Xie, Yi; Shao, Yongfu; Sun, Weiliang; Ye, Guoliang; Zhang, Xinjun; Xiao, Bingxiu; Guo, Junming^*

来源：Biomarkers in Medicine, 2018, 12(1): 11-20.

DOI：10.2217/bmm-2017-0114

• biomarker
• CircRNA
• diagnostics
• divergent primers
• gastric cancer
• gene expression
• Hsa_circ_0074362
• noncoding RNA
• RT-PCR
• translational medicine

Aim: To explore the diagnostic value of hsa_circ_0074362 in the screening of gastric cancer. Methods: The expression levels of hsa_circ_0074362 in 127 gastric cancer tissues and paired adjacent normal tissues, 83 gastritis tissues and six gastric cancer cell lines were first detected by quantitative reverse transcription-polymerase chain reaction. Then, the relationship between its levels and clinicopathological factors of patients with gastric cancer was analyzed. Finally, a receiver operating characteristic curve was established. Results: Hsa_circ_0074362 levels were significantly downregulated in gastric cancer tissues, gastritis tissues and gastric cancer cell lines. Its levels were associated with lymphatic metastasis. Conclusion: Hsa_circ_0074362 probably plays a role in the initiation of gastric cancer and may be a potential biomarker of gastric cancer.

• 出版日期2018-1
• 单位宁波大学