摘要
Tissue-resident memory T (T-RM) cells occupy peripheral and lymphoid tissues where they confer protection against local infection. While epithelial CD8(+) T-RM cells coexpress CD69 and CD103, CD103(-)memory cells have been described in various organs and are often presumed non-recirculating based on their expression of CD69. We found that both CD69(+)CD103(+) and CD69(+)CD103(-)memory cells populated the thymus upon transfer of CD8(+) effector T cells into uninfected recipients. Transcriptionally and phenotypically, CD103(+) thymic cells resembled non-lymphoid TRM cells, whereas CD69(+)CD103(-)cells displayed a profile that was more closely related to recirculating cells. Although CD69 was required for optimal CD103(+) T-RM formation, its expression alone did not identify permanently resident cells, as CD69(+)CD103(-)cells disappeared from the thymus following antibody-mediated depletion of recirculating cells. Our findings highlight a distinct migration potential of phenotypically divergent thymic CD8(+) memory T cells and emphasise the inadequacy of CD69 as a marker of tissue residency.
- 出版日期2016-12