Postpartum thrombotic microangiopathic syndrome

作者：Owens Michelle Y^*; Martin James N Jr; Wallace Kedra; Keiser Sharon D; Parrish Marc R; Tam Kiran B Tam; Martin Rick W

来源：Transfusion and Apheresis Science, 2013, 48(1): 51-57.

DOI：10.1016/j.transci.2012.05.016

• Postpartum plasma exchange
• Thrombotic microangiopathy
• HELLP syndrome

Objective: Characterization of syndromes for patients with life-threatening, progressively worsening hemolysis-elevated-liver-enzymes-and-platelet (HELLP) syndrome-like diseases and with thrombotic microangiopathies. %26lt;br%26gt;Retrospective study design: Patients who underwent postpartum plasma-exchange (PPEX) for preeclampsia-related, and microangiopathy/coagulopathy illnesses unresponsive to medical therapy between 1994 and 2008 in our center and elsewhere. %26lt;br%26gt;Results: Nine patients were treated with PPEX in our center with 78% maternal survival. Treatment with PPEX increased platelet levels (p = 0.048), decreased serum lactic dehydrogenase (p = 0.0012) and aspartate aminotransferase (p = 0.0001). %26lt;br%26gt;Conclusion: Nineteen patients from publications combined with our patients suggest five categories of postpartum thrombotic microangiopathy syndrome that exhibit HELLP syndrome criteria and respond to PPEX.

• 出版日期2013-2