Association of the GCKR rs780094 polymorphism with metabolic traits including carotid intima-media thickness in Japanese community-dwelling men, but not in women

作者：Murata Mori Fumi; Hayashida Naomi; Ando Takao; Ikeoka Toshiyuki; Nakazato Mio; Sekita Harutaka; Abiru Norio; Yamasaki Hironori; Maeda Takahiro; Kawakami Atsushi; Takamura Noboru^*

来源：Clinical Chemistry and Laboratory Medicine, 2014, 52(2): 289-295.

DOI：10.1515/cclm-2013-0092

• carotid intima-media thickness
• glucokinase regulator protein gene
• sex difference
• triglyceride
• type 2 diabetes mellitus

Background: The glucokinase regulator gene (GCKR) rs780094 has been shown to be strongly associated with some metabolic traits and atherosclerotic parameters, while the association between GCKR rs780094 and carotid intima-media thickness (CIMT) has not been fully investigated in the general population. The associations between the GCKR rs780094 genotype and metabolic traits including CIMT were examined in a Japanese community-dwelling population. %26lt;br%26gt;Methods: A total of 2491 Japanese adults (907 men and 1584 women) who participated in a medical screening program for the general population from 29 to 94 years of age during 2008 to 2010 were enrolled. GCKR rs780094 was genotyped by the TaqMan polymerase chain reaction method, and associations with metabolic markers including CIMT were evaluated. %26lt;br%26gt;Results: GCKR rs780094 AA genotype was significantly associated with higher TG (p %26lt; 0.001 vs. GG), lower HDL-C (p = 0.021 vs. GG), and lower HbA(1c) (p = 0.023 vs. GG). The AA genotype showed significantly thinner CIMT (p = 0.001 vs. GX). These associations were seen only in men. %26lt;br%26gt;Conclusions: GCKR rs780094 was associated with TG, HDL-C, and HbA(1c) levels, as well as with CIMT in Japanese community-dwelling men, but not women.

• 出版日期2014-2