An efficient and scalable synthesis of N-(benzyloxycarbonyl)- and N-(methyloxycarbonyl)-(S)-vinylglycinol

作者：Lumbroso Alexandre; Coeffard Vincent; Le Grognec Erwan^*; Beaudet Isabelle; Quintard Jean Paul

来源：Tetrahedron Letters, 2010, 51(24): 3226-3228.

DOI：10.1016/j.tetlet.2010.04.059

• Chiral beta-amino alcohol
• Vinylglycine
• Amino acid
• Preparative procedure

An efficient and scalable synthesis of N-(benzyloxycarbonyl)- and N-(methyloxycarbonyl)-(S)-vinylglycinol has been reported starting from the commercially available (L)-methionine. The scale-up preparation consisted of 5 steps and delivered up to 50 g of the desired N-protected beta-amino alcohols in 32% and 36% overall yields.

• 出版日期2010-6-16