Angiogenic factors and pre-eclampsia: an early marker is needed

作者：Stepan Holger^*

来源：Clinical Science, 2009, 116(3-4): 231-232.

DOI：10.1042/CS20080598

• angiogenesis
• plasma marker
• pre-eclampsia
• splice variant
• vascular endothelial growth factor (165)b (VEGF(165)b)
• vascular permeability

Pre-eclampsia, a pregnancy complication characterized by hypertension and proteinuria, is still a major cause of neonatal and maternal mortality, and acute and long-term morbidities for both mother and neonate. There is mounting evidence that an imbalance between angiogenic factors, such as VEGF (vascular endothelial growth factor) or PIGF (placental growth factor), and factors inhibiting angiogenesis, such as sFItI (soluble fms-like tyrosine kinase I) and sEng (soluble endoglin), are closely related to the pathogenesis of pre-eclampsia. In the present issue of Clinical Science, Bills and co-workers report that VEGF(165)b, an alternative splice variant of the VEGF pre-mRNA, is up-regulated in women with normal pregnancy and that this increase was delayed or diminished in women who developed pre-eclampsia. Thus this protein could serve (alone or in combination with other parameters) as a new marker for risk assessment in terms of pre-eclampsia.

• 出版日期2009-2