Analysis of HLA antigens in Croatian patients with psoriasis

作者：Kastelan M^*; Gruber F; Cecuk E; Kerhin Brkljacic V; Brkljacic Surkalovic L; Kastelan A

来源：Acta Dermato-Venereologica, 2000, 12-13.

• psoriasis
• HLA antigens
• polymerase chain reaction

In common with most autoimmune diseases, psoriasis is associated with some HLA antigens, We studied the distribution of HLA antigens in Croatian patients with psoriasis: 108 patients were divided into groups according to family history and age of disease onset. KLA antigens were analyzed serologically and HLA-C alleles were analyzed using polymerase chain reaction. We found significant increases in HLA-AZ, -B17, -B37 and -B13 antigens and highly significant increases in HLA-Cw*0602 and DR7 antigens in psoriatic patients compared with controls. Patients with type I psoriasis (early onset, positive family history) showed highly significant associations with Cw*0602 [p<0.00001; relative risk (RR)=14.45] and DR7 (p<0.00001; RR=15.09) antigens. Patients with type II psoriasis (late onset, no family history) had a significant association with Cw*03 antigen (p=0.008; RR=0.17). In conclusion, HLA-B13, -B17, Cw*0602 and -DR7 antigens are associated with a significant risk of psoriasis in the Croatian population and the Cw*0602 allele has the strongest association, especially for type I psoriasis.

• 出版日期2000