A tumor-suppressive microRNA, miR-504, inhibits cell proliferation and promotes apoptosis by targeting FOXP1 in human glioma

作者：Cui, Run; Guan, Yanlei; Sun, Chuanqi; Chen, Ling; Bao, Yijun; Li, Guangyu; Qiu, Bo; Meng, Xin; Pang, Chao; Wang, Yunjie^*

来源：Cancer Letters, 2016, 374(1): 1-11.

DOI：10.1016/j.canlet.2016.01.051

• Glioma
• microRNA
• miR-504
• Forkhead box protein P1
• Downregulation

MicroRNAs (miRNAs) have been proposed as useful prognostic cancer biomarkers and as potential molecular targets for treating various cancers. Previous findings have indicated that miR-504 is dysregulated and involved in tumorigenesis of several types of cancer. However, the biological role of miR-504 in glioma remains unclear. In this study, we showed that miR-504 expression was markedly decreased in both glioma tissues and cell lines and that miR-504 downregulation significantly correlated with aggressive clinicopathological features and poor prognosis for glioma patients. In addition, miR-504 overexpression inhibited cell proliferation, induced cell cycle arrest, and promoted apoptosis in glioma cell lines. Furthermore, we identified forkhead box protein P1 (FOXP1) as a direct target of miR-504 using microarray analysis and a luciferase assay. Moreover, we demonstrated that miR-504 regulated glioma tumorigenesis by downregulating FOXP1 expression. Our results suggest that miR-504 might function as an important suppressor of glioma tumorigenesis and could serve as a promising candidate for therapeutic applications in glioma treatment.

• 出版日期2016-4-28
• 单位中国医科大学