Up-regulation of p21-activated kinase 1 by in vitro treatment with interleukin 1-beta and its increased expression in ovarian endometriotic cysts

作者：Lee Mi Young; Kim Sung Hoon^*; Ihm Hyo Jin; Kim Chung Hoon; Kang Byung Moon

来源：Fertility and Sterility, 2011, 96(2): 508-511.

DOI：10.1016/j.fertnstert.2011.05.082

• P21-activated kinase 1 (Pak1)
• endometrium
• endometriosis
• interleukin-1 beta (IL-1 beta)
• pathogenesis
• cytokine

We evaluated whether the proinflammatory cytokines can regulate p21-activated kinase (Pak1) expression in endometrial cells as well as whether its expression is increased in endometriotic cysts. We found that interleukin-1 beta up-regulates Pak1 expression in endometrial stromal cells (ESC) and that the immunoreactivity of Pak1 is increased in the endometriotic cysts. (Fertil Steril (R) 2011;96:508-11.

• 出版日期2011-8