Atherosclerotic plaque metabolism in high cardiovascular risk subjects - A subclinical atherosclerosis imaging study with F-18-NaF PET-CT

作者：de Oliveira Santos Manuel^*; Castelo Branco Miguel; Silva Rodolfo; Gomes Andreia; Chichorro Nuno; Abrunhosa Antero; Donato Paulo; de Lima Joao Pedroso; Pego Mariano; Goncalves Lino; Ferreira Maria Joao

来源：Atherosclerosis, 2017, 260: 41-46.

DOI：10.1016/j.atherosclerosis.2017.03.014

• Sodium fluoride
• Atherosclerosis
• Positron-emission tomography
• Molecular imaging
• Cardiovascular diseases

Background and aims: Atherosclerotic plaque molecular imaging with F-18-sodium fluoride (NaF) in positron emission tomography with computed tomography (PET-CT) provides potential discrimination between active unstable microcalcification and established dormant calcification. We aimed to study F-18-NaF atherosclerotic plaque uptake in high cardiovascular (CV) risk participants and its associations with CV risk factors, coronary calcium score and thoracic fat volume.
Methods: High CV risk hypertensive individuals from a single centre were prospectively scanned with F-18-NaF-PET-CT in the coronary, aortic and carotideal arteries. Atherosclerotic plaque F-18-NaF uptake was expressed as Corrected Uptake per Lesion (CUL): maximum standard uptake value in each vascular territory subtracted by mean blood pool activity.
Results: Mean age was 64 years, 56% male and 96% Caucasian (n = 25). Ninety six per cent of the subjects showed F-18-NaF uptake in the aorta (CUL 0.9 +/- 0.3), 40% in the carotid arteries (median CUL 0.0, IQR 0.0 -0.7) and 64% in the coronary arteries (0.4, IQR 0.0-0.6). Individuals with >= five risk factors (60%) had increased overall F-18-NaF uptake (1.1 +/- 0.3 vs. 0.7 +/- 0.3, p < 0.01), which was positively correlated with predicted fatal CV risk - SCORE (r = 0.49, p = 0.01). There was no correlation between F-18-NaF uptake in the coronary arteries and calcium score (p = 0.87). Thoracic fat was moderately correlated with overall CUL (r = 0.41, p = 0.04).
Conclusions: In a high CV risk group, F-18-NaF atherosclerotic plaque uptake was related to the burden of CV risk factors and thoracic fat volume, but there was no association between coronary uptake and calcium score.

• 出版日期2017-5