A clean photometric method for the determination of losartan potassium in pharmaceuticals exploiting light scattering effect and employing a multicommuted flow analysis approach

作者：Lima Manoel J A; Reis Boaventura F^*

来源：Talanta, 2017, 164: 183-188.

DOI：10.1016/j.talanta.2016.11.011

• Multicommuted flow analysis
• Losartan potassium
• Green chemistry
• Spectrophotometry
• LED photometer
• Pharmaceutical samples

This paper describes an environmentally friendly procedure for the determination of losartan potassium (Los-K) in pharmaceuticals. The photometric method was based on the light scattering effect due to particles suspension, which were formed by the reaction of Los-K with Cu (II) ions. The method was automated employing a multicommuted flow analysis approach, implemented using solenoid mini-pumps for fluid propelling and a homemade LED based photometer. Under the optimized experimental conditions, the procedure showed a linear relationship in the concentration range of 23.2-417.6 mg L-1 (r=0.9997, n=6), a relative standard deviation of 1.61% (n=10), a limit of detection (3.3*sigma) estimated to be 12.1 mg L-1, and a sampling rate of 140 determinations per hour. Each determination consumed 12 mu g of copper (II) acetate and generated 0.54 mL of waste.

• 出版日期2017-3-1