A 10-second sprint does not blunt hormonal counter-regulation to subsequent hypoglycaemia

作者：Paramalingam, N.; Fournier, P. A.; Davey, R. J.; Roby, H. C.; Smith, G. J.; Shetty, V. B.; Guelfi, K. J.; Davis, E. A.; Jones, T. W.^*

来源：Diabetic Medicine, 2017, 34(10): 1440-1446.

DOI：10.1111/dme.13396

• TYPE-1 DIABETES-MELLITUS
• COUNTERREGULATORY RESPONSES
• ANTECEDENT HYPOGLYCEMIA
• GLUCOSE REQUIREMENTS
• MAINTAIN EUGLYCEMIA
• AFTERNOON EXERCISE
• GLUCAGON-SECRETION
• PHYSICAL-ACTIVITY
• INTENSE EXERCISE
• INDIVIDUALS

AimTo investigate whether a 10-second (s) sprint impairs the counter-regulatory response to subsequent hypoglycaemia.
MethodsNine people (five male, four female) with Type 1 diabetes, aged 21.1 4.5 years, performed a 10-s rest or a 10-s maximum-effort sprint in random order on different days, while subjected to an euinsulinaemic-euglycaemic clamp. This was followed by a hyperinsulinaemic-hypoglycaemic glucose clamp 2.5 h later to induce hypoglycaemia for 40 min. At timed intervals, the counter-regulatory hormonal responses to hypoglycaemia were measured. Blood pressure, heart rate and hypoglycaemic symptoms were also assessed.
ResultsDuring the hypoglycaemic clamp, epinephrine, norepinephrine, growth hormone and cortisol levels increased significantly from baseline, and their responses were similar after both rest and sprint conditions. In particular, plasma epinephrine rose eightfold, from 197 103 pmol/l to 1582 1118 pmol/l after the rest condition, and from 219 119 pmol/l to 1900 898 pmol/l after the sprint condition.
ConclusionA 10-s sprint is unlikely to blunt the subsequent hormonal counter-regulation to hypoglycaemia in individuals with Type 1 diabetes.

• 出版日期2017-10