Molecules in seminal plasma related to platelets in preeclampsia

作者：Antonio Garcia Montalvo Ivan; Mayoral Andrade Gabriel; Perez Campos Mayoral Laura; Pina Canseco Socorro; Martinez Cruz Ruth; Martinez Cruz Margarito; Zenteno Edgar; Perez Campos Mayoral Eduardo; Velasco Gallegos Itandehui; Teresa Hernandez Huerta Maria; Matias Perez Diana; Perez Campos Eduardo

来源：Medical Hypotheses, 2016, 93: 27-29.

DOI：10.1016/j.mehy.2016.05.009

• Prostaglandins
• Oxylipins
• Gangliosides
• Seminal fluid
• Platelets
• Preeclampsia

Objective: Prostaglandins present in seminal fluid are actively involved in vascular and non-vascular smooth muscle maintenance, reproduction, and inflammatory processes. Seminal plasma contains molecules, such as oxylipins, which possess cell signaling functions. Several studies have shown that specific molecules in seminal fluid can increase passive diffusion, and cause interactions in the female reproductive tract. This may provoke a cascade of cellular and molecular changes in general health and certain diseases.
Objective: This study examines the hypothesis that the molecules in seminal fluid are involved in platelet activity. The molecules diffuse through cells and membranes, affecting Hoxa 10, binding ganglioside pathways, and acting over platelet function. When these molecules are at low levels, they may trigger prothrombotic states, explaining the pathophysiology of haemostatic response, such as preeclampsia, and increased risk of cardiovascular disease.

• 出版日期2016-8