Alphaxalone inhibits growth, migration and invasion of rat C6 malignant glioma cells

作者：Sun, Huawei; Zheng, Xiaoke; Zhou, Yuehan; Zhu, Wenbo; Ou, Yanqiu; Shu, Minfeng; Gao, Xiuren; Leng, Tiandong^*; Qiu, Pengxin; Yan, Guangmei

来源：Steroids, 2013, 78(10): 1041-1045.

DOI：10.1016/j.steroids.2013.06.008

• Malignant glioma
• Alphaxalone
• Proliferation
• Invasion

Malignant gliomas are the most devastating and aggressive brain tumors affecting the central nervous system. The insidious growth and infiltration are the most prominent characteristics of malignant gliomas, which render the current therapies for malignant gliomas including surgery, radiation and chemotherapy unsuccessful. Inhibition of infiltration as well as proliferation in combination with surgery might be more effective in the treatment of malignant gliomas. In the current study, we demonstrate the alphaxalone (3-hydroxypregnane-11,20-dione) could effectively inhibit the proliferation of C6 glioma cells in a concentration dependent manner. Moreover, this compound could also suppress the migration and invasion of C6 glioma cells at a concentration without causing significant cytotoxicity. Except the in vitro anti-glioma activity, alphaxalone effectively delayed the growth of rat C6 malignant glioma xenografts in vivo. Together, these findings suggest alphaxalone might be a promising candidate for the treatment of malignant gliomas and may also provide helpful clues for anti-glioma drugs development in future.

• 出版日期2013-10
• 单位广东省心血管病研究所; 桂林医学院; 广东省人民医院; 中山大学