A 4-year dopamine transporter (DAT) imaging study in neuroleptic-naive first episode schizophrenia patients

作者：Mane Anna^*; Gallego Judith; Lomena Francisco; Javier Mateos Jose; Fernandez Egea Emilio; Horga Guillermo; Cot Albert; Pavia Javier; Bernardo Miguel; Parellada Eduard

来源：Psychiatry Research: Neuroimaging , 2011, 194(1): 79-84.

DOI：10.1016/j.pscychresns.2011.03.004

• Basal ganglia
• Outcome
• Negative
• Longitudinal

Alterations in the dopaminergic system have long been implicated in schizophrenia. A key component in dopaminergic neurotransmission is the striatal dopamine transporter (DAT). To date, there have been no longitudinal studies evaluating the course of DAT in schizophrenia. A 4-year follow-up study was therefore conducted in which single photon emission computed tomography was used to measure DAT binding in 14 patients and 7 controls. We compared the difference over time in [I-123]FP-CIT striatal/occipital uptake ratios (SOUR) between patients and controls and the relationship between this difference and both symptomatology and functional outcome at follow-up. We also calculated the relationship between baseline SOUR, symptoms and functional outcome at follow-up. There were no statistically significant differences between patients' SOUR changes over time and those of controls. A significant negative correlation was observed between patients' SOUR changes over time and negative symptomatology at follow-up. A significant negative correlation was also found between baseline SOUR in patients and negative symptomatology, and there was a significant association between lower SOUR at baseline and poor outcome. Although the study found no overall differences in DAT binding during follow-up between schizophrenia patients and controls, it demonstrated that differences in DAT binding relate to patients' characteristics at follow-up.

• 出版日期2011-10-31