Acute Decrease in HDL Cholesterol Associated With Exposure to Welding Fumes

作者：Rice Mary Berlik^*; Cavallari Jenn; Fang Shona; Christiani David

来源：Journal of Occupational and Environmental Medicine, 2011, 53(1): 17-21.

DOI：10.1097/JOM.0b013e3182028d20

Objective: To investigate acute changes in circulating lipids after exposure to relatively high levels of particulate matter through welding. Methods: Using a repeated measures panel study, lipid levels before and after welding and personal exposures to fine particulate matter (PM(2.5)) were measured in 36 male welders over 63 exposure and/or control days. Results: There was a trend toward decrease in HDL(-2.3mg/dL, P = 0.08) 18 hours after welding. This effect became significant (-2.6 mg/dL, P = 0.05) after adjustment for possible confounders. The effect was strongest (-4.3 mg/dL, P = 0.02) among welders who did not weld the day before the study. There were no significant changes in other lipids associated with welding or PM2.5 exposure. Conclusion: Welding exposure was associated with an acute decrease in circulating HDL, which may relate to the inflammatory and proatherosclerotic effects of fine particle exposure.

• 出版日期2011-1